Mcu Gene Summary [Mouse]
Enables calcium channel activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Acts upstream of or within cell migration; cell population proliferation; and generation of precursor metabolites and energy. Located in mitochondrion. Part of calcium channel complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and limb segment. Orthologous to human MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mcu |
| Official Name | mitochondrial calcium uniporter [Source:MGI Symbol;Acc:MGI:3026965] |
| Ensembl ID | ENSMUSG00000009647 |
| Bio databases IDs | |
| Aliases | mitochondrial calcium uniporter |
| Synonyms | 2010012O16Rik, C10orf42, CCDC109A, Coiled-coil domain containing 109a, D130073L02Rik, Gm64, HsMCU, LOC100502977, mitochondrial calcium uniporter |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium channel
- protein binding
- uniporter
- identical protein binding
- ion channel
- transporter
- Mitochondrial calcium uniporter
Pathways
Biological processes and signaling networks where the Mcu gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- streptozotocin-induced diabetes
- neoplasia
- colon cancer
- Parkinson disease with dementia
role in cell
- expression in
- growth
- cell death
- metabolism in
- production in
- migration
- phosphorylation in
- differentiation
- signaling in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcu gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- elevation of mitochondrial calcium ion concentration
- positive regulation of neutrophil chemotaxis
- glucose homeostasis
- mitochondrial calcium ion homeostasis
- positive regulation of insulin secretion
- positive regulation of mitochondrial fission
- calcium-mediated signaling
- protein oligomerization
- mitochondrial calcium ion transport
Cellular Component
Where in the cell the gene product is active
- calcium channel complex
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium channel activity
- uniporter activity