Immt Gene Summary [Mouse]
Acts upstream of or within mitochondrial calcium ion homeostasis and neuron cellular homeostasis. Located in mitochondrial intermembrane space. Is expressed in several structures, including cranial ganglion; gut; lung; medulla oblongata basal plate mantle layer; and skeletal musculature. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Immt |
| Official Name | inner membrane protein, mitochondrial [Source:MGI Symbol;Acc:MGI:1923864] |
| Ensembl ID | ENSMUSG00000052337 |
| Bio databases IDs | |
| Aliases | inner membrane protein, mitochondrial |
| Synonyms | 1700082C19Rik, D830041H16RIK, HMP, inner membrane mitochondrial protein, inner membrane protein, mitochondrial, Mic60, Mic60/3, MICOS60, MINOS2, Mitofilin, P87, P87/89, P89, PIG4, PIG52 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Immt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mitochondrial presequence
- Arginine and glutamate-rich 1
- membrane attachment signal
- protein binding
- Mitochondrial inner membrane protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- heart failure
- glioblastoma
- glioblastoma cancer
- Parkinson disease
- colorectal adenocarcinoma
- colorectal carcinomagenesis
role in cell
- apoptosis
- cell death
- expression in
- proliferation
- epithelial-mesenchymal transition
- transmembrane potential
- formation
- cell viability
- integrity
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- myofilaments
- Golgi cisternae rim
- mitochondrial cristae
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial intermembrane space
- mitochondrial inner membrane
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Immt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron homeostasis
- cristae formation
- mitochondrial calcium ion homeostasis
- inner mitochondrial membrane organization
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial crista junction
- mitochondrion
- membrane
- mitochondrial sorting and assembly machinery complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding