Tsg101 Gene Summary [Mouse]
Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tsg101 |
| Official Name | tumor susceptibility gene 101 [Source:MGI Symbol;Acc:MGI:106581] |
| Ensembl ID | ENSMUSG00000014402 |
| Bio databases IDs | |
| Aliases | tumor susceptibility gene 101 |
| Synonyms | CC2, Rw, TSG10, tumor susceptibility 101, tumor susceptibility gene 101, tumour susceptibility 101, tumour susceptibility gene 101, VPS23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tsg101 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- virion binding
- transcription regulator
- transcription co-activator
- transcription co-repressor
- coiled-coil domain
- leucine zipper domain
- GAG-binding domain
- proline rich domain
- GPP motif
- ubiquitin binding domain
- PR domain
- headpiece domain
- PTAP-binding site
- ubiquitin protein ligase binding
- steadiness box
- calcium-dependent protein binding
- Ezrin/radixin/moesin, alpha-helical domain
- oligomerization domain
- helical domain
- UBCc_UEV
- ubiquitin binding
- protein binding
- Vps23 core domain
- DNA binding
- ubiquitin conjugase-like domain
- binding protein
- stalk region
- protein homodimerization
- P(S/T)AP domain
Pathways
Biological processes and signaling networks where the Tsg101 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- unspecified disease
- ovarian carcinoma
- epithelial ovarian cancer
- small cell lung carcinoma
- small cell lung cancer
- cardiac hypertrophy
- infection by HIV-1
role in cell
- growth
- expression in
- proliferation
- morphology
- activation in
- cell cycle progression
- phosphorylation in
- survival
- signaling in
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- soluble fraction
- detergent-soluble membrane fractions
- prostasome
- intracellular compartment
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- midbody
- granules
- cytosol
- endosomal membrane
- nucleoli
- early endosomes
- late endosomes
- multivesicular bodies
- mitotic spindle
- filopodial tip
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tsg101 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- regulation of MAP kinase activity
- protein modification process
- membrane fission
- negative regulation of epidermal growth factor-activated receptor activity
- negative regulation of cell proliferation
- non-lytic virus budding
- endosome to lysosome transport
- negative regulation of epidermal growth factor receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- cell division
- keratinocyte differentiation
- extracellular transport
- release of virus from host
- regulation of cell growth
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- positive regulation of ubiquitin-dependent endocytosis
- regulation of cell cycle
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- ESCRT I complex
- late endosome
- multivesicular body
- nucleolus
- plasma membrane
- early endosome membrane
- late endosome membrane
- early endosome
- centrosome
- endosome
- extracellular vesicular exosome
- cytoplasm
- cytosol
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- virion binding
- DNA binding
- protein homodimerization activity
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding
- transcription corepressor activity
- calcium-dependent protein binding