Actr1a Gene Summary [Mouse]
Predicted to enable ATP binding activity. Located in myelin sheath. Is expressed in cerebral cortex; ganglia; and trigeminal nerve. Orthologous to human ACTR1A (actin related protein 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actr1a |
| Official Name | ARP1 actin-related protein 1A, centractin alpha [Source:MGI Symbol;Acc:MGI:1858964] |
| Ensembl ID | ENSMUSG00000025228 |
| Bio databases IDs | |
| Aliases | ARP1 actin-related protein 1A, centractin alpha |
| Synonyms | actin related protein 1A, actin-RPV, Actr1a predicted, alpha-Arp1, Alpha-centractin, ARP1, Arp1A, ARP1 actin-related protein 1A, centractin alpha, ARP1 actin-related protein 1A, centractin α, CENTROSOME ASSOCIATED ACTIN, CTRN1, α-Arp1, α-centractin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Actr1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
regulates
- dynein heavy chain
- LIC
- dynein light chain
- motor
- dynein intermediate chain
role in cell
- binding in
- misalignment
- cohesion
- translocation
- binding
- misalignment in
- cohesion in
- translocation in
- motor function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- microtubule aster fraction
- membrane fraction
- microtubule cytoskeleton
- manchette
- cell cortex
- Nucleus
- centrosome
- Golgi Apparatus
- centriole
- cytosol
- spindle pole
- spindle fibers
- astral microtubules
- pseudopodia
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Actr1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centrosome
- extracellular vesicular exosome
- dynactin complex
- cytoplasm
- cell cortex
- cytosol
- microtubule associated complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding