Rps6kb1 Gene Summary [Mouse]
Enables protein serine/threonine/tyrosine kinase activity. Involved in several processes, including cellular response to type II interferon; long-chain fatty acid import into cell; and negative regulation of TORC2 signaling. Acts upstream of or within several processes, including behavioral fear response; cellular response to dexamethasone stimulus; and negative regulation of signal transduction. Located in mitochondrion. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; early conceptus; leg muscle; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps6kb1 |
| Official Name | ribosomal protein S6 kinase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1270849] |
| Ensembl ID | ENSMUSG00000020516 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase, polypeptide 1 |
| Synonyms | 2610318I15RIK, 4732464A07RIK, 70S6K, P70, p70/85s6k, p70-alpha, p70s6k, P70S6K1, p70 S6K-alpha, p70S6 kinase, p70 S6K-α, p70(S6K)-α, p70-α, PS6K, ribosomal protein S6 kinase B1, ribosomal protein S6 kinase, polypeptide 1, S6K, S6K1, S6K-beta-1, S6K-β-1, STK14A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps6kb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- protein kinase
- PDK1 regulatory site
- ATP-binding domain
- ATP binding
- Protein kinase domain
- identical protein binding
- activation loop
- TOS domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- Protein kinase C terminal domain
- Proline-directed phosphorylation site
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- protein binding
- PDZ-domain binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- ribosomal protein S6 kinase
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Rps6kb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Adipogenesis pathway
- AMPK Signaling
- Apelin Endothelial Signaling Pathway
- CNTF Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- ErbB Signaling
- ERK5 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HIF1α Signaling
- IGF-1 Signaling
- Insulin Receptor Signaling
- Melanocyte Development and Pigmentation Signaling
- Neuregulin Signaling
- p38 MAPK Signaling
- Regulation of eIF4 and p70S6K Signaling
- Role of Tissue Factor in Cancer
- Thrombin Signaling
- TR/RXR Activation
- UVA-Induced MAPK Signaling
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- neoplastic cell transformation
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- hypoxia
- papillary thyroid carcinoma
- papillary thyroid cancer
- tumorigenesis
- breast cancer
role in cell
- proliferation
- expression in
- production in
- apoptosis
- accumulation in
- phosphorylation in
- growth
- migration
- survival
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- glutaminergic synapse
- cell surface
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- synaptosomes
- synapse
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps6kb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- long-chain fatty acid import
- positive regulation of translation
- response to xenobiotic stimulus
- positive regulation of skeletal muscle tissue growth
- response to leucine
- response to toxin
- response to mechanical stimulus
- cellular response to insulin stimulus
- positive regulation of smooth muscle cell proliferation
- response to ethanol
- response to glucose stimulus
- skeletal muscle contraction
- apoptotic process
- G1/S transition of mitotic cell cycle
- response to electrical stimulus involved in regulation of muscle adaptation
- positive regulation of smooth muscle cell migration
- response to testosterone stimulus
- cell migration
- skeletal muscle atrophy
- germ cell development
- cellular response to nutrient
- signal transduction
- TOR signaling cascade
- regulation of glucose import
- negative regulation of insulin receptor signaling pathway
- positive regulation of mitotic cell cycle
- behavioral fear response
- long-term memory
- phosphatidylinositol-mediated signaling
- negative regulation of apoptotic process
- cellular response to growth factor stimulus
- negative regulation of extrinsic apoptotic signaling pathway
- regulation of synaptic transmission
- response to lipopolysaccharide
- response to glucagon stimulus
- cellular response to interferon-gamma
- cellular response to dexamethasone stimulus
- peptidyl-serine phosphorylation
- response to nutrient levels
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial outer membrane
- neuron projection
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- ribosomal protein S6 kinase activity
- ATP binding
- identical protein binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- PDZ domain binding
- protein kinase activity
- peptide binding
- protein serine/threonine kinase activity
- protein phosphatase 2A binding