Sod3 Gene Summary [Mouse]
Enables superoxide dismutase activity. Acts upstream of or within response to hypoxia. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and neural ectoderm. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sod3 |
| Official Name | superoxide dismutase 3, extracellular [Source:MGI Symbol;Acc:MGI:103181] |
| Ensembl ID | ENSMUSG00000072941 |
| Bio databases IDs | |
| Aliases | superoxide dismutase 3, extracellular |
| Synonyms | EC-SOD, ECSODPT, superoxide dismutase 3, superoxide dismutase 3, extracellular |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sod3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- superoxide dismutase
- heparin binding domain
- enzyme
- protein binding
- Copper/zinc superoxide dismutase (SODC)
- Cu-Zn_Superoxide_Dismutase
Pathways
Biological processes and signaling networks where the Sod3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastasis
- hepatic fibrosis
- chronic obstructive pulmonary disease
- hepatic steatosis
- neoplastic cell transformation
- edema
- glycogen storage disease type II
- chronic sinusitis
- hypertrophic scarring
role in cell
- expression in
- fragmentation
- apoptosis
- phosphorylation in
- activation in
- production in
- shortening
- cellular infiltration by
- maturation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- Nucleus
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sod3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- removal of superoxide radicals
- response to copper ion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- heparin binding
- superoxide dismutase activity
- binding, bridging