Tusc2 Gene Summary [Mouse]
Acts upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Located in mitochondrion. Is expressed in liver and metanephros. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tusc2 |
| Official Name | tumor suppressor 2, mitochondrial calcium regulator [Source:MGI Symbol;Acc:MGI:1931086] |
| Ensembl ID | ENSMUSG00000010054 |
| Bio databases IDs | |
| Aliases | tumor suppressor 2, mitochondrial calcium regulator |
| Synonyms | 1190001E22Rik, C3orf11, FUS1, Lgcc, PAP, PDAP2, tumor suppressor 2, mitochondrial calcium regulator, tumour suppressor 2, mitochondrial calcium regulator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tusc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Tumour suppressor candidate 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hematological neoplasia
- thrombosis
- cancer
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- arteritis
- glomerulonephritis
- asthenozoospermia
regulated by
- EIF4E
- mir-378 (includes others)
role in cell
- proliferation
- differentiation
- survival
- growth
- number
- colony formation
- maturation
- phagocytosis by
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tusc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- regulation of mitochondrial membrane potential
- natural killer cell differentiation
- phagocytosis
- regulation of reactive oxygen species metabolic process
- cell maturation
- negative regulation of interleukin-17 production
- positive regulation of interleukin-10 production
- neutrophil mediated killing of gram-negative bacterium
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding