Tex14 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity. Involved in several processes, including intercellular bridge organization; mitotic spindle assembly checkpoint signaling; and nuclear chromosome segregation. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of cytokinesis. Located in intercellular bridge; kinetochore; and midbody. Is expressed in germ cell of ovary; germ cell of testis; ovary; and primordial germ cell of gonad. Human ortholog(s) of this gene implicated in spermatogenic failure 23. Orthologous to human TEX14 (testis expressed 14, intercellular bridge forming factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tex14 |
| Official Name | testis expressed gene 14 [Source:MGI Symbol;Acc:MGI:1933227] |
| Ensembl ID | ENSMUSG00000010342 |
| Bio databases IDs | |
| Aliases | testis expressed gene 14 |
| Synonyms | CT113, SgK307, SPGF23, testis expressed 14, intercellular bridge forming factor, testis expressed gene 14 intercellular bridge forming factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tex14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Ankyrin repeats (many copies)
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Ankyrin repeats (3 copies)
- protein binding
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spermatogenic failure 23
- soft tissue sarcoma cancer
- rhabdomyosarcoma
- hypertension
- ocular hypertension
regulates
role in cell
- formation
- spindle checkpoint
- organization
- abnormal morphology
- attachment
- ciliogenesis in
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- midbody
- cytoplasmic bridges
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tex14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- intercellular bridge organization
- male meiosis
- attachment of spindle microtubules to kinetochore
- negative regulation of cytokinesis
- mitotic sister chromatid separation
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- extracellular vesicular exosome
- cytoplasm
- kinetochore
- midbody
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- protein kinase activity