Eya4 Gene Summary [Mouse]
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within middle ear morphogenesis and sensory perception of sound. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; future brain; sensory organ; and urinary system. Used to study otitis media. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eya4 |
| Official Name | EYA transcriptional coactivator and phosphatase 4 [Source:MGI Symbol;Acc:MGI:1337104] |
| Ensembl ID | ENSMUSG00000010461 |
| Bio databases IDs | |
| Aliases | EYA transcriptional coactivator and phosphatase 4 |
| Synonyms | B130023L16RIK, CMD1J, DFNA10, EYA, EYA transcriptional coactivator and phosphatase 4, Eyes absent 4 homolog |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eya4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatase
- protein binding
- Haloacid Dehalogenase-like Hydrolases
- eyes absent protein conserved domain
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- neoplasia
- brain cancer
- atrial fibrillation
- metastasis
- COVID-19
- side effect
- mucopolysaccharidosis, MPS-IV-A
- autosomal dominant 10 deafness
- dilated cardiomyopathy 1J
role in cell
- accumulation in
- expression in
- migration
- proliferation
- cell death
- homologous recombination dependent double-stranded DNA break repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eya4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA repair
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- inner ear development
- cell differentiation
- anatomical structure development
- anatomical structure morphogenesis
- visual perception
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- metal ion binding