Pdhx Gene Summary [Mouse]
Predicted to enable molecular adaptor activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Involved in pyruvate decarboxylation to acetyl-CoA. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; musculature; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and sarcoma. Orthologous to human PDHX (pyruvate dehydrogenase complex component X). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdhx |
| Official Name | pyruvate dehydrogenase complex, component X [Source:MGI Symbol;Acc:MGI:1351627] |
| Ensembl ID | ENSMUSG00000010914 |
| Bio databases IDs | |
| Aliases | pyruvate dehydrogenase complex, component X |
| Synonyms | Ac1164, DIHYDROLIPOAMIDE DEHYDROGENASE-binding, DLDBP, E3BP, OPDX, PDHXD, PDX1, proX, pyruvate dehydrogenase complex component X, pyruvate dehydrogenase complex, component X |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdhx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Biotinyl_lipoyl_domains
- e3 binding domain
- lipoyl domain
- sucB
- pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
- 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
- Biotin-requiring enzyme
- enzyme
- protein binding
- aldehyde or oxo group:NAD or NADP oxidoreductase
- pyruvate dehydrogenase
Pathways
Biological processes and signaling networks where the Pdhx gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- COVID-19
- non-insulin-dependent diabetes mellitus
- obsessive-compulsive disorder
- pyruvate dehydrogenase E3-binding protein deficiency
- hereditary disorder
- Leigh syndrome
- autosomal recessive nonsyndromic mental retardation
- pyruvate dehydrogenase e1-alpha deficiency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdhx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process from pyruvate
Cellular Component
Where in the cell the gene product is active
- pyruvate dehydrogenase complex
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- transferase activity, transferring acyl groups
- protein binding
- pyruvate dehydrogenase (NAD+) activity