Steap4 Gene Summary [Mouse]
Enables cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Involved in fat cell differentiation. Acts upstream of or within copper ion import; iron import into cell; and iron ion import across cell outer membrane. Located in endosome and plasma membrane. Is expressed in brain. Orthologous to human STEAP4 (STEAP4 metalloreductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Steap4 |
| Official Name | STEAP family member 4 [Source:MGI Symbol;Acc:MGI:1923560] |
| Ensembl ID | ENSMUSG00000012428 |
| Bio databases IDs | |
| Aliases | STEAP family member 4 |
| Synonyms | 1110021O17Rik, SchLAH, STAMP-2, STEAP4 metalloreductase, STEAP family member 4, TIARP, TNFAIP9, Tnf alpha-induced adipose, Tnf α-induced adipose |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Steap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- FAD binding
- electron carrier
- cupric reductase
- ferric-chelate reductase
- metal ion oxidising:NAD or NADP oxidoreductase
- NADP oxidoreductase coenzyme F420-dependent
- Cytochrome_b_N
- enzyme
- heme binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- epithelial cancer
- insulin resistance
- rheumatoid arthritis
- colorectal cancer
- dextran sodium sulfate-induced colitis
- diabetes mellitus
- liver cancer
- hepatocellular carcinoma
- hepatic steatosis
role in cell
- proliferation
- expression in
- phosphorylation in
- number
- uptake by
- mitochondrial respiration in
- autophagic flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Steap4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- iron assimilation
- fat cell differentiation
- protein homotrimerization
- copper ion import
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- extracellular vesicular exosome
- endosome
- membrane
- Golgi membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FAD binding
- ferric-chelate reductase (NADPH) activity
- metal ion binding
- electron carrier activity
- cupric reductase activity
- heme binding