Kif11 Gene Summary [Mouse]
Predicted to enable plus-end-directed microtubule motor activity and protein kinase binding activity. Acts upstream of or within mitotic centrosome separation and spindle assembly. Predicted to be located in cytosol; microtubule; and spindle. Predicted to be part of protein-containing complex. Predicted to be active in mitotic spindle; nucleus; and spindle microtubule. Predicted to colocalize with spindle pole. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif11 |
| Official Name | kinesin family member 11 [Source:MGI Symbol;Acc:MGI:1098231] |
| Ensembl ID | ENSMUSG00000012443 |
| Bio databases IDs | |
| Aliases | kinesin family member 11 |
| Synonyms | EG5, HKSP, Kif8, Kifl1, Kinesin-5, kinesin family member 11, KNSL1, MCLMR, TRIP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNase Y N-terminal region
- protein kinase binding
- Kinesin-associated microtubule-binding
- Myosin and Kinesin motor domain
- protein binding
- motor domain
- microtubule motor protein
- Kinesin motor, catalytic domain
- microtubule binding
- head-stalk region
- stalk region
- Kinesin motor domain
- tail domain
Pathways
Biological processes and signaling networks where the Kif11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- lung squamous cell carcinoma
- invasive breast cancer
- colon adenocarcinoma
- rectum cancer
- asthma
- non-insulin-dependent diabetes mellitus
- neoplasia
- systemic lupus erythematosus
- septic shock
role in cell
- expression in
- apoptosis
- number
- cell viability
- growth
- proliferation
- quantity
- formation
- formation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule aster fraction
- intracellular membrane-bounded organelle
- spindle apparatus
- Cytoplasm
- pericentrosomal region
- basal bodies
- centrosome
- centriole
- microtubules
- microtubule bundles
- postmitotic bridges
- cytosol
- spindle pole
- spindle fibers
- nerve ending
- mitotic spindle
- perikaryon
- axon branches
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle organization
- spindle elongation
- mitotic spindle organization
- mitotic centrosome separation
- microtubule-based movement
- regulation of mitotic centrosome separation
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle microtubule
- mitotic spindle
- membrane
- spindle
- spindle pole
- cytosol
- macromolecular complex
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- microtubule motor activity
- protein binding
- plus-end-directed microtubule motor activity
- microtubule binding