Rrp1b Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Involved in negative regulation of GTPase activity and regulation of RNA splicing. Located in euchromatin; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and sternum. Orthologous to human RRP1B (ribosomal RNA processing 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrp1b |
| Official Name | ribosomal RNA processing 1B [Source:MGI Symbol;Acc:MGI:1919712] |
| Ensembl ID | ENSMUSG00000058392 |
| Bio databases IDs | |
| Aliases | ribosomal RNA processing 1B |
| Synonyms | 2600005C20Rik, D030064A17, KIAA0179, mKIAA0179, Nnp1, NNP1L, PPP1R136, RGD1305633, ribosomal RNA processing 1B, RRP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rrp1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- protein binding
- Nucleolar protein,Nop52
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- gastric epithelial cancer
- gastric carcinoma
role in cell
- expression in
- apoptosis
- cell death
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- granular components
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rrp1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- negative regulation of GTPase activity
- RNA splicing
- regulation of RNA splicing
- positive regulation of apoptotic process
- apoptotic process
- mRNA processing
- rRNA processing
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- granular component
- heterochromatin
- nucleus
- euchromatin
- cytosol
- chromosome
- nucleolus
- preribosome, small subunit precursor
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- transcription coactivator activity