Trnt1 Gene Summary [Mouse]
Predicted to enable cytidylyltransferase activity; protein homodimerization activity; and tRNA binding activity. Predicted to be involved in rescue of stalled ribosome and tRNA metabolic process. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trnt1 |
| Official Name | tRNA nucleotidyl transferase, CCA-adding, 1 [Source:MGI Symbol;Acc:MGI:1917297] |
| Ensembl ID | ENSMUSG00000013736 |
| Bio databases IDs | |
| Aliases | tRNA nucleotidyl transferase, CCA-adding, 1 |
| Synonyms | 2410043H24Rik, 2610044E04Rik, 9830143O18RIK, C76540, CCA1, CGI-47, MtCCA, mt-Trat, RPEM, SIFD, tRNA nucleotidyl transferase 1, tRNA nucleotidyl transferase, CCA-adding, 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trnt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Poly A polymerase head domain
- tRNA binding
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- Probable RNA and SrmB- binding site of polymerase A
- nucleotidyltransferase
- tRNA adenylyltransferase
- ATP binding
- protein homodimerization
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay
- retinal dystrophy
- retinitis pigmentosa and erythrocytic microcytosis
- hereditary disorder
role in cell
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trnt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- tRNA 3'-end processing
- tRNA 3'-terminal CCA addition
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tRNA adenylyltransferase activity
- ATP binding
- RNA polymerase activity
- protein homodimerization activity
- metal ion binding
- tRNA binding