Slc25a11 Gene Summary [Mouse]
Enables oxoglutarate:malate antiporter activity. Involved in gluconeogenesis and malate-aspartate shuttle. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a11 |
| Official Name | solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 [Source:MGI Symbol;Acc:MGI:1915113] |
| Ensembl ID | ENSMUSG00000014606 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 |
| Synonyms | 2310022P18Rik, 2oxoc, 2-Oxoglutarate carrier, Malate-AKG transporter, Malate-oxoglutarate transporter, Mitochondrial 2oxoglutarate/Malate Carrier, OGC, PGL6, PPGL6, SLC20A4, solute carrier family 25 member 11, solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxoglutarate/malate antiporter
- Mitochondrial carrier protein
- protein binding
- alpha-ketoglutarate transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- paragangliomas type 6
- Sengers syndrome
- idiopathic dilated cardiomyopathy
- proximal tubular toxicity
regulates
- insulin
- glutathione
- 2-oxoglutaric acid
- PGAM5
role in cell
- apoptosis
- molecular cleavage in
- gluconeogenesis in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Plasma Membrane
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alpha-ketoglutarate transport
- sulfate transport
- lipid transport
- gluconeogenesis
- thiosulfate transport
- oxaloacetate transport
- succinate transmembrane transport
- malate transmembrane transport
- phosphate ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- plasma membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- oxoglutarate:malate antiporter activity
- RNA binding
- protein binding
- antiporter activity
- oxaloacetate transmembrane transporter activity
- succinate transmembrane transporter activity
- malate transmembrane transporter activity
- thiosulfate transmembrane transporter activity
- sulfate transmembrane transporter activity