Brd9 Gene Summary [Mouse]
Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of SWI/SNF complex. Is expressed in central nervous system; female reproductive system; and urinary system. Orthologous to human BRD9 (bromodomain containing 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd9 |
| Official Name | bromodomain containing 9 [Source:MGI Symbol;Acc:MGI:2145317] |
| Ensembl ID | ENSMUSG00000057649 |
| Bio databases IDs | |
| Aliases | bromodomain containing 9 |
| Synonyms | AL022779, bromodomain containing 9, LAVS3040, PRO9856, SMARCI2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding
- Bromodomain
- Domain of unknown function (DUF3512)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastrointestinal stromal tumor
- gastrointestinal stromal neoplasia
- lung carcinoma
- lung carcinoma process
role in cell
- expression in
- binding in
- apoptosis
- proliferation
- osteoclastogenesis
- colony formation by
- homologous recombination repair in
- missegregation in
- non-homologous end joining in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brd9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of cell differentiation
- positive regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- histone acetyl-lysine binding