Ppp1r1a Gene Summary [Mouse]
Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; gonad; intraembryonic coelom; sensory organ; and skin. Orthologous to human PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r1a |
| Official Name | protein phosphatase 1, regulatory inhibitor subunit 1A [Source:MGI Symbol;Acc:MGI:1889595] |
| Ensembl ID | ENSMUSG00000022490 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory inhibitor subunit 1A |
| Synonyms | 0610038N18Rik, I-1, IPP1, protein phosphatase 1 regulatory inhibitor subunit 1A, protein phosphatase 1, regulatory (inhibitor) subunit 1A, protein phosphatase 1, regulatory inhibitor subunit 1A, Protein phosphatase inhibitor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1r1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- type 1 serine/threonine specific protein phosphatase inhibitor
- phosphoprotein phosphatase
- phosphatase
- protein binding
- Protein phosphatase inhibitor 1/DARPP-32
Pathways
Biological processes and signaling networks where the Ppp1r1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- amyotrophic lateral sclerosis
- ischemic cardiomyopathy
- dilated cardiomyopathy
- atrial fibrillation
role in cell
- activation
- growth
- long-term potentiation
- shortening
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1r1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen metabolic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein binding