Chfr Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein metabolic process; protein destabilization; and protein polyubiquitination. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chfr |
| Official Name | checkpoint with forkhead and ring finger domains [Source:MGI Symbol;Acc:MGI:2444898] |
| Ensembl ID | ENSMUSG00000014668 |
| Bio databases IDs | |
| Aliases | checkpoint with forkhead and ring finger domains |
| Synonyms | 5730484M20RIK, C230082M18, checkpoint with forkhead and ring finger domains, RNF116, RNF196 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chfr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cysteine rich domain with multizinc binding regions
- nucleotide binding
- ubiquitin protein ligase activity
- Forkhead associated domain
- enzyme
- Ring finger domain
- protein binding
- forkhead associated (FHA) domain superfamily
- ubiquitin ligase-like domain
- FHA domain
- PBZ domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
- cysteine rich domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- cancer
- metastasis
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
role in cell
- proliferation
- expression in
- activation in
- survival
- phosphorylation in
- cell viability
- cellular infiltration by
- growth
- degradation in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chfr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- protein destabilization
- mitotic cell cycle checkpoint
- protein polyubiquitination
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding