Kif22 Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic metaphase chromosome alignment; and sister chromatid cohesion. Located in chromatin and spindle. Is expressed in cerebral cortex ventricular layer; cortical plate; and inner cell mass. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif22 |
| Official Name | kinesin family member 22 [Source:MGI Symbol;Acc:MGI:109233] |
| Ensembl ID | ENSMUSG00000030677 |
| Bio databases IDs | |
| Aliases | kinesin family member 22 |
| Synonyms | A-328A3.2, AU021460, C81217, KID, Kif22a, kinesin family member 22, KNSL4, LOC102553262, OBP, OBP-1, OBP-2, SEMDJL2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- DNA binding domain
- Myosin and Kinesin motor domain
- ATP-binding domain
- nuclear localization sequence
- coiled-coil domain
- protein binding
- motor domain
- Helix-hairpin-helix motif
- head domain
- microtubule motor protein
- DNA binding
- Kinesin motor, catalytic domain
- microtubule binding
- competence protein ComEA helix-hairpin-helix repeat region
- Kinesin motor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- organismal death
- spondyloepimetaphyseal dysplasia with joint laxity type 2
- developmental bone disease
- small cell lung cancer
- melanoma
- melanoma cancer
role in cell
- expression in
- glycolysis in
- proliferation
- apoptosis
- abnormal morphology
- cohesion
- cytokinesis failure in
- cohesion in
- chromosomal congression
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- spindle pole bodies
- cytosol
- chromosome
- spindle pole
- spindle fibers
- nuclear speckles
- mitotic spindle
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- DNA repair
- metaphase plate congression
- microtubule-based movement
- mitotic metaphase plate congression
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- nuclear speck
- cytosol
- kinesin complex
- kinetochore
- chromatin
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- microtubule motor activity
- protein binding
- microtubule binding