Erp29 Gene Summary [Mouse]
Predicted to enable protein homodimerization activity and protein-folding chaperone binding activity. Involved in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in cell surface. Is expressed in Meckel's cartilage and pancreas epithelium. Orthologous to human ERP29 (endoplasmic reticulum protein 29). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Erp29 |
| Official Name | endoplasmic reticulum protein 29 [Source:MGI Symbol;Acc:MGI:1914647] |
| Ensembl ID | ENSMUSG00000029616 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum protein 29 |
| Synonyms | 1200015M03Rik, 2810446M09Rik, C12orf8, endoplasmic reticulum protein 29, ERp28, ERp31, HEL-S-107, PDIA9, PDI-DB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Erp29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ERp29c
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein homodimerization
- protein binding
- chaperone binding
- transporter
Pathways
Biological processes and signaling networks where the Erp29 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dysferlinopathy
- infection by murine hepatitis virus
role in cell
- proliferation
- expression in
- apoptosis
- accumulation in
- formation
- degradation in
- formation in
- cell-cell contact
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular matrix fraction
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cell surface
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- smooth endoplasmatic reticulum
- phagosomes
- ER lumenal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Erp29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- negative regulation of gene expression
- negative regulation of protein secretion
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- intracellular protein transport
- protein folding
- protein secretion
- protein unfolding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- melanosome
- smooth endoplasmic reticulum
- membrane
- endoplasmic reticulum
- transport vesicle
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein disulfide isomerase activity
- chaperone binding