S1pr2

Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation; regulation of postsynapse assembly; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse S1pr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the S1pr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse S1pr2 gene, providing context for its role in the cell.