Cemip2 Gene Summary [Mouse]
Enables hyalurononglucosaminidase activity. Involved in hyaluronan catabolic process. Predicted to be located in cytosol; nucleolus; and plasma membrane. Is expressed in several structures, including heart; integumental system; nervous system; sensory organ; and tooth. Orthologous to human CEMIP2 (cell migration inducing hyaluronidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cemip2 |
| Official Name | cell migration inducing hyaluronidase 2 [Source:MGI Symbol;Acc:MGI:1890373] |
| Ensembl ID | ENSMUSG00000024754 |
| Bio databases IDs | |
| Aliases | cell migration inducing hyaluronidase 2 |
| Synonyms | cell migration inducing hyaluronidase 2, KIAA1412, TMEM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cemip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G8 domain
- extracellular domain
- Interleukin-like EMT inducer
- calcium ion binding
- enzyme
- hyalurononglucosaminidase
- Domains similar to the Pancreatic-derived factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- single major depressive episode
- Graves ophthalmopathy
- fibrosis
- acute myeloid leukemia
role in cell
- expression in
- growth
- phosphorylation in
- quantity
- production in
- migration
- formation
- formation in
- invasion by
- substrate adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cemip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- hyaluronan catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- hyalurononglucosaminidase activity
- cadherin binding
- calcium ion binding
- carbohydrate binding