Slamf6 Gene Summary [Mouse]
Involved in natural killer cell differentiation and natural killer cell proliferation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human SLAMF6 (SLAM family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slamf6 |
| Official Name | SLAM family member 6 [Source:MGI Symbol;Acc:MGI:1353620] |
| Ensembl ID | ENSMUSG00000015314 |
| Bio databases IDs | |
| Aliases | SLAM family member 6 |
| Synonyms | CD352, KAL1, KAL1b, KALI, KALIb, Ly108, NK-T-B-antigen, NTB-A, RGD1561848, SF2000, SLAM family member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slamf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAP binding domain
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
- immunoreceptor tyrosine switch motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- systemic lupus erythematosus
- Crohn disease
- Graves disease
- infection by bacteria
- infection by parasite
role in cell
- production in
- cytotoxicity
- activation
- number
- differentiation
- degranulation
- killing by
- activation in
- association in
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slamf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- positive regulation of interferon-gamma production
- T-helper 17 cell lineage commitment
- positive regulation of interleukin-17 production
- T cell activation
- positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding