Adcy9 Gene Summary [Mouse]
Enables adenylate cyclase activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and in utero embryonic development. Located in membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy9 |
| Official Name | adenylate cyclase 9 [Source:MGI Symbol;Acc:MGI:108450] |
| Ensembl ID | ENSMUSG00000005580 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 9 |
| Synonyms | AC9, ACIX, ACtp10, adenylate cyclase 9, D16Wsu65e, LOC100362008, mKIAA0520 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adcy9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- adenylate cyclase
- Class III nucleotidyl cyclases
- enzyme
- protein binding
- Adenylyl- / guanylyl cyclase, catalytic domain
- C1 domain (from adenylate cyclase)
- C2 domain (from adenylate cyclase)
Pathways
Biological processes and signaling networks where the Adcy9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Gustation Pathway
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- breast carcinoma
- obesity
- hypertension
- asthma
- gout
- metabolic syndrome X
- overnutrition
- localization-related epilepsy
- cerebral amyloid angiopathy
regulated by
- tacrolimus
- quinpirole
- POPDC1
- tetradecanoylphorbol acetate
- forskolin
- beta-estradiol
- Immunoglobulin
- LH
- POMC
- Ca2+
regulates
- cyclic AMP
- adenosine triphosphate
role in cell
- production in
- retraction
- retraction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cellular membrane
- basal bodies
- cytosol
- apical membrane
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adcy9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cAMP biosynthetic process
- in utero embryonic development
- signal transduction
- adenylate cyclase-activating adrenergic receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- membrane
- cytosol
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- adenylate cyclase activity