Gsdmd Gene Summary [Mouse]
Enables phospholipid binding activity; transcription coactivator activity; and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within ceramide biosynthetic process; plasma membrane repair; and protein maturation. Located in cytosol; extracellular space; and mitochondrial membrane. Part of NLRP3 inflammasome complex. Is active in plasma membrane. Is expressed in several structures, including aorta; gut; liver; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsdmd |
| Official Name | gasdermin D [Source:MGI Symbol;Acc:MGI:1916396] |
| Ensembl ID | ENSMUSG00000022575 |
| Bio databases IDs | |
| Aliases | gasdermin D |
| Synonyms | 1810036L03Rik, DF5L, DFNA5L, FKSG10, FLJ12150, gasdermin D, GsdmD-1, GSDMDC1, M2-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gsdmd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- transcription co-activator
- binding protein
- channel/pore class transporter
- phosphatidylinositol-4,5-bisphosphate binding
- Gasdermin PUB domain
- protein binding
- Gasdermin pore forming domain
- phosphatidylinositol binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute kidney injury
- edema
- renal fibrosis
- multiple sclerosis
- insomnia
- atopic dermatitis
- low-grade glioma
- glioma formation
- organismal death
role in cell
- killing
- apoptosis
- activation in
- formation
- production in
- binding in
- expression in
- proliferation
- migration
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- organelle lumens
- cellular membrane
- Plasma Membrane
- cytosol
- mitochondrial membrane
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gsdmd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- defense response to Gram-negative bacterium
- positive regulation of inflammatory response
- protein homooligomerization
- pore complex assembly
- defense response to bacterium
- protein secretion
- inflammatory response
- innate immune response
- pyroptosis
- positive regulation of interleukin-1 beta production
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrial membrane
- specific granule lumen
- membrane
- cytosol
- extracellular region
- plasma membrane
- NLRP3 inflammasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- wide pore channel activity
- phosphatidylinositol-4-phosphate binding
- phosphatidylserine binding
- protein binding
- phosphatidic acid binding