Il27ra Gene Summary [Mouse]
Enables interleukin-27 receptor activity. Involved in negative regulation of T cell extravasation; negative regulation of T-helper 17 type immune response; and negative regulation of cytokine production. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of type II interferon production; and regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il27ra |
| Official Name | interleukin 27 receptor, alpha [Source:MGI Symbol;Acc:MGI:1355318] |
| Ensembl ID | ENSMUSG00000005465 |
| Bio databases IDs | |
| Aliases | interleukin 27 receptor, alpha |
| Synonyms | CRL1, IL-27R, IL-27R-alpha, IL-27R-α, interleukin 27 receptor, alpha, interleukin 27 receptor subunit alpha, interleukin 27 receptor subunit α, interleukin 27 receptor, α, TCCR, WSX-1, zcytor1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il27ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-27 receptor
- cytoplasmic domain
- FN3
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il27ra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- epithelial neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- infection
- colitis
- weight loss
role in cell
- expression in
- differentiation
- proliferation
- apoptosis
- quantity
- activation
- number
- activation in
- binding
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il27ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- negative regulation of neuron apoptotic process
- negative regulation of interleukin-6 production
- negative regulation of T-helper 17 type immune response
- immune response
- regulation of isotype switching to IgG isotypes
- cytokine-mediated signaling pathway
- negative regulation of T cell extravasation
- positive regulation of interferon-gamma production
- positive regulation of T-helper 1 type immune response
- negative regulation of type 2 immune response
- negative regulation of interleukin-17 production
- interleukin-27-mediated signaling pathway
- negative regulation of tumor necrosis factor production
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-27 receptor activity
- protein binding
- transmembrane signaling receptor activity
- cytokine binding