Egfl8 Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including diaphragm; genitourinary system; gut; hemolymphoid system gland; and trigeminal nerve. Orthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Egfl8 |
| Official Name | EGF-like domain 8 [Source:MGI Symbol;Acc:MGI:1932094] |
| Ensembl ID | ENSMUSG00000015467 |
| Bio databases IDs | |
| Aliases | EGF-like domain 8 |
| Synonyms | C6orf8, EGF-like domain 8, EGF like domain multiple 8, EGF-like-domain, multiple 8, NG3, VE-statin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Egfl8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EMI domain
- protein binding
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Egfl8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- anatomical structure development
Cellular Component
Where in the cell the gene product is active
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- receptor binding