Atp6v0e Gene Summary [Mouse]
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Part of proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; cranium; heart; nervous system; and sensory organ. Orthologous to human ATP6V0E1 (ATPase H+ transporting V0 subunit e1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0e |
| Official Name | ATPase, H+ transporting, lysosomal V0 subunit E [Source:MGI Symbol;Acc:MGI:1328318] |
| Ensembl ID | ENSMUSG00000015575 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V0 subunit E |
| Synonyms | ATP6H, ATP6K, ATP6V0E, ATPase, H+ transporting, lysosomal V0 subunit E, ATPase H+ transporting V0 subunit e1, dsr-1, Dsr-1A, H+-ATPase E subunit, M9.2, V1H, Vma21, Vma21p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v0e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- H+-transporting two-sector ATPase
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- ATP synthase subunit H
- transporter
- ATPase activity, coupled to transmembrane movement of ions
Pathways
Biological processes and signaling networks where the Atp6v0e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- infection by virus
regulates
- ATP6V0E1
- H+
- CD4
- CD8 (family)
- TF
role in cell
- Clathrin mediated endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- lysosome membrane
- endosomal membrane
- clathrin-coated vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v0e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- regulation of macroautophagy
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- phagocytic vesicle membrane
- proton-transporting V-type ATPase, V0 domain
- endosome membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity, coupled to transmembrane movement of ions
- protein binding
- proton-transporting ATPase activity, rotational mechanism