Slc5a1 Gene Summary [Mouse]
Enables D-glucose:sodium symporter activity. Involved in intestinal D-glucose absorption; regulation of transporter activity; and renal D-glucose absorption. Acts upstream of or within D-glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane and brush border. Is expressed in alimentary system; brain; and urinary system. Human ortholog(s) of this gene implicated in glucose-galactose malabsorption. Orthologous to human SLC5A1 (solute carrier family 5 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc5a1 |
| Official Name | solute carrier family 5 (sodium/glucose cotransporter), member 1 [Source:MGI Symbol;Acc:MGI:107678] |
| Ensembl ID | ENSMUSG00000011034 |
| Bio databases IDs | |
| Aliases | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
| Synonyms | D22S675, NAGT, SGLT-1, SGLT1a, solute carrier family 5 member 1, solute carrier family 5 (sodium/glucose cotransporter), member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc5a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pentose transporter
- hexose transporter
- glucose:sodium symporter
- galactose:sodium symporter
- fucose transporter
- myo-inositol:sodium symporter
- alpha-glucoside transporter
- protein binding
- galactose transporter
- Solute carrier families 5 and 6-like; solute binding domain
- water transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc5a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular death
- glucose-galactose malabsorption
- heart failure
- streptozotocin-induced diabetes
- non-insulin-dependent diabetes mellitus
- renal glucosuria
- non-obstructive hypertrophic cardiomyopathy
- diabetes mellitus
- insulin-dependent diabetes mellitus
- stage III chronic kidney disease
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- intracellular membrane-bounded organelle
- organelle
- cell surface
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- intercellular junctions
- apical membrane
- basolateral membrane
- nuclear envelope
- early endosomes
- brush border
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc5a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- intestinal D-glucose absorption
- pentose transport
- transepithelial water transport
- alpha-glucoside transport
- galactose transport
- fucose transport
- myo-inositol transport
- renal glucose absorption
Cellular Component
Where in the cell the gene product is active
- intracellular organelle
- early endosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- brush border membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pentose transmembrane transporter activity
- protein binding
- water transmembrane transporter activity
- D-glucose transmembrane transporter activity
- galactose:sodium symporter activity
- alpha-glucoside transmembrane transporter activity
- fucose transmembrane transporter activity
- galactose transmembrane transporter activity
- myo-inositol:sodium symporter activity
- glucose transmembrane transporter activity
- glucose:sodium symporter activity