Coa3 Gene Summary [Mouse]
Predicted to be involved in mitochondrial cytochrome c oxidase assembly and positive regulation of mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 14. Orthologous to human COA3 (cytochrome c oxidase assembly factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coa3 |
| Official Name | cytochrome C oxidase assembly factor 3 [Source:MGI Symbol;Acc:MGI:1098757] |
| Ensembl ID | ENSMUSG00000017188 |
| Bio databases IDs | |
| Aliases | cytochrome C oxidase assembly factor 3 |
| Synonyms | 1810033A19Rik, CCDC56, COX25, cytochrome C oxidase assembly factor 3, D11Ertd99e, hCOA3, HSPC009, MC4DN14, MITRAC12, RGD1564337 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytochrome c oxidase assembly factor 3
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coa3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex IV assembly
- positive regulation of mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding