Cxcl2 Gene Summary [Mouse]
Predicted to enable chemokine activity. Involved in response to molecule of bacterial origin. Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; floor plate; gut; respiratory system; and skin. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcl2 |
| Official Name | chemokine (C-X-C motif) ligand 2 [Source:MGI Symbol;Acc:MGI:1340094] |
| Ensembl ID | ENSMUSG00000058427 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) ligand 2 |
| Synonyms | CINC-2a, Cinc3, C-X-C motif chemokine ligand 2, Gro2, Gro-alpha, GROb, Gro beta, Gro-α, Gro β, lncRNA of Cxcl2 locus, Mgsa-b, MIP-2, MIP-2a, Mip2 alpha, Mip2 α, Scyb, Scyb15, Scyb2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- cytokine
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Cxcl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17A in Arthritis
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- metastasis
- neutrophilia
- Marfan syndrome
- weight loss
- Staphylococcus aureus pneumonia
- dextran sodium sulfate-induced colitis
- infectious disorder
- Sjögren syndrome
role in cell
- cell death
- adhesion
- expression in
- differentiation
- growth
- activation in
- proliferation
- production in
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- plasma