Fstl1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity and heparin binding activity. Involved in endothelial cell differentiation; endothelial cell migration; and negative regulation of apoptotic process. Acts upstream of or within hematopoietic stem cell homeostasis. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; limb; and sensory organ. Used to study pulmonary emphysema. Orthologous to human FSTL1 (follistatin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fstl1 |
| Official Name | follistatin-like 1 [Source:MGI Symbol;Acc:MGI:102793] |
| Ensembl ID | ENSMUSG00000022816 |
| Bio databases IDs | |
| Aliases | follistatin-like 1 |
| Synonyms | Follistatin-like, follistatin-like 1, FRP, FSL1, FSTL, MIR198, OCC-1, TSC-36 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fstl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- EF-hand domain pair
- EFh
- protein binding
- KAZAL_FS
- heparin binding
- Follistatin/Osteonectin-like EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- bacterial sepsis
- gastric cancer
- airway hyperresponsiveness
- myocardial infarction
- neoplasia
- hepatic fibrosis
- hepatic steatosis
- age-related macular degeneration
- arthritis
phenotypes
- decreased circulating creatinine level
- decreased fasting circulating glucose level
- impaired glucose tolerance
- increased circulating cholesterol level
- increased heart weight
- abnormal breathing pattern
- abnormal bronchiole morphology
- abnormal cervical atlas morphology
- abnormal cervical axis morphology
- abnormal costal cartilage morphology
- abnormal digit morphology
- abnormal hindlimb stylopod morphology
- abnormal hindlimb zeugopod morphology
- abnormal kidney pelvis morphology
- abnormal larynx morphology
- abnormal long bone morphology
- abnormal lung development
- abnormal lung epithelium morphology
- abnormal lung lobe morphology
- abnormal lung morphology
- abnormal metacarpal bone morphology
- abnormal neural tube morphology
- abnormal pulmonary alveolar sac morphology
- abnormal pulmonary alveolus morphology
- abnormal rib morphology
- abnormal skeleton morphology
- abnormal spine curvature
- abnormal trachea morphology
- abnormal tracheal cartilage morphology
- abnormal tracheal ciliated epithelium morphology
- abnormal type II pneumocyte morphology
- abnormal ureter development
- abnormal ureter morphology
- abnormal ureter urothelium morphology
- absent patella
- absent sesamoid bone of gastrocnemius
- asymmetric sternocostal joints
- bowed fibula
- camptomelia
- cyanosis
- decreased alveolar lamellar body number
- decreased bone ossification
- decreased neutrophil cell number
- decreased surfactant secretion
- decreased tracheal cartilage ring number
- decreased type I pneumocyte number
- dilated ureter
- fused phalanges
- hydronephrosis
- hydroureter
- increased glycogen level
- increased lymphocyte cell number
- increased type II pneumocyte number
- kidney papillary atrophy
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- perinatal lethality complete penetrance
- primary atelectasis
- pulmonary hyperplasia
- respiratory distress
- small kidney
- trachea stenosis
- ureter stenosis
role in cell
- expression in
- production in
- migration
- phosphorylation in
- apoptosis
- differentiation
- activation in
- proliferation
- maturation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- vesicles
- endoplasmic reticulum lumen
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fstl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- negative regulation of apoptotic process
- cell differentiation
- endothelial cell differentiation
- endothelial cell migration
- regulation of BMP signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heparin binding