Arl5b Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Is expressed in testis. Orthologous to human ARL5B (ARF like GTPase 5B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl5b |
| Official Name | ADP-ribosylation factor-like 5B [Source:MGI Symbol;Acc:MGI:1923119] |
| Ensembl ID | ENSMUSG00000017418 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 5B |
| Synonyms | 4930587A11Rik, ADP-ribosylation factor-like 5B, ARF like GTPase 5B, ARL8, AW146430 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- 50S ribosome-binding GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- suicide attempt
- carcinoma in situ
- epithelial cancer in situ
- COVID-19
- preeclampsia
- chronic periodontal disease
- sudden cardiac arrest
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- expression in
- production in
- clearance
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity