Xylt2 Gene Summary [Mouse]
Enables protein xylosyltransferase activity. Involved in glycosaminoglycan biosynthetic process. Acts upstream of or within heparin proteoglycan biosynthetic process. Predicted to be located in extracellular space. Predicted to be active in Golgi apparatus. Is expressed in alimentary system; cardiovascular system; integumental system; and nervous system. Used to study polycystic kidney disease. Human ortholog(s) of this gene implicated in pseudoxanthoma elasticum. Orthologous to human XYLT2 (xylosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xylt2 |
| Official Name | xylosyltransferase II [Source:MGI Symbol;Acc:MGI:2444797] |
| Ensembl ID | ENSMUSG00000020868 |
| Bio databases IDs | |
| Aliases | xylosyltransferase II |
| Synonyms | E030002B02Rik, PXYLT2, SOS, XT2, XT-II, xylosyltransferase 2, xylosyltransferase II, xylT-II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xylt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Core-2/I-Branching enzyme
- Xylosyltransferase C terminal
- protein xylosyltransferase
- enzyme
- manganese ion binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- fibrosis
- polycystic liver disease
- hyperplasia
- pseudoxanthoma elasticum
- spondyloocular syndrome
- polycystic kidney disease
- hydronephrosis
role in cell
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xylt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- chondroitin sulfate proteoglycan biosynthetic process
- heparan sulfate proteoglycan biosynthetic process
- glycosaminoglycan biosynthetic process
- heparin biosynthetic process
- glycosaminoglycan metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- manganese ion binding
- protein xylosyltransferase activity