Usp14 Gene Summary [Mouse]
Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp14 |
| Official Name | ubiquitin specific peptidase 14 [Source:MGI Symbol;Acc:MGI:1928898] |
| Ensembl ID | ENSMUSG00000047879 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 14 |
| Synonyms | 2610005K12Rik, 2610037B11RIK, ax, C78769, nmf375, TGT, ubiquitin specific peptidase 14, Ubiquitin specific protease 14, UBP14, Ubp6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding
- ubiquitin-like domain
- Peptidase_C19
- endopeptidase inhibitor
- Ubiquitin family
- cysteine endopeptidase
- binding protein
- Ubl1_cv_Nsp3_N-like
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- Ubiquitin homologues
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- head and neck squamous cell carcinoma
- hepatocellular carcinoma
- neoplasia
- liver cancer
- epithelial cancer
- cancer
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
phenotypes
- preweaning lethality complete penetrance
- Purkinje cell degeneration
- abnormal brain commissure morphology
- abnormal brain morphology
- abnormal brainstem morphology
- abnormal cerebellar granule cell morphology
- abnormal cingulum morphology
- abnormal dentate gyrus morphology
- abnormal hindbrain morphology
- abnormal hippocampus pyramidal cell morphology
- abnormal limbic system morphology
- abnormal lumbar vertebrae morphology
- abnormal mechanical nociception
- abnormal miniature endplate potential
- abnormal nervous system physiology
- abnormal neuromuscular synapse morphology
- abnormal neurotransmitter secretion
- abnormal pons morphology
- abnormal pontine nuclei morphology
- abnormal spinal cord morphology
- abnormal spinal cord white matter morphology
- abnormal spinal nerve morphology
- abnormal synaptic transmission
- ataxia
- axonal dystrophy
- decreased body size
- decreased body weight
- decreased corpus callosum size
- decreased hippocampal commissure size
- decreased midbrain size
- decreased paired-pulse facilitation
- decreased post-tetanic potentiation
- female infertility
- impaired coordination
- impaired synaptic plasticity
- increased neuron apoptosis
- increased synaptic depression
- limb grasping
- male infertility
- muscle degeneration
- muscle spasm
- muscle weakness
- muscular atrophy
- paralysis
- paraparesis
- perinatal lethality complete penetrance
- postnatal growth retardation
- premature death
- priapism
- reduced long term potentiation
- short lumbar vertebrae
- small cerebellum
- small hippocampus
- tremors
- weakness
role in cell
- cell viability
- proliferation
- apoptosis
- expression in
- phosphorylation in
- migration
- growth
- invasion by
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cell surface
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- nucleoli
- synaptosomes
- synapse
- cytoplasmic vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of proteasomal protein catabolic process
- innate immune response
- synaptic transmission
- regulation of chemotaxis
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytoplasmic vesicle
- cytosol
- proteasome complex
- synapse
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- endopeptidase inhibitor activity
- proteasome binding
- protein binding
- cysteine-type endopeptidase activity