Ptgis Gene Summary [Mouse]
Enables prostaglandin-I synthase activity. Involved in cyclooxygenase pathway. Acts upstream of or within decidualization and embryo implantation. Located in cytoplasm and nucleus. Is active in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgis |
| Official Name | prostaglandin I2 (prostacyclin) synthase [Source:MGI Symbol;Acc:MGI:1097156] |
| Ensembl ID | ENSMUSG00000017969 |
| Bio databases IDs | |
| Aliases | prostaglandin I2 (prostacyclin) synthase |
| Synonyms | CYP8, CYP8A1, Pcs, PGI2 synthase, PGIS, PROSTACYCLIN, Prostacyclin synthase, prostaglandin I2 (prostacyclin) synthase, prostaglandin I2 synthase, PTGI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptgis often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- prostaglandin-I synthase
- enzyme
- protein binding
- heme binding
Pathways
Biological processes and signaling networks where the Ptgis gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- COVID-19
- bipolar disorder
- schizophrenia
- cervical posterior longitudinal ligament ossification
- lung cancer
- organismal death
- endometriosis
role in cell
- expression in
- cell viability
- apoptosis
- activation in
- proliferation
- oxidation in
- production in
- transactivation in
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- caveolae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptgis gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of inflammatory response
- icosanoid metabolic process
- apoptotic signaling pathway
- positive regulation of execution phase of apoptosis
- positive regulation of angiogenesis
- negative regulation of nitric oxide biosynthetic process
- cyclooxygenase pathway
- cellular response to interleukin-6
- prostaglandin biosynthetic process
- cellular response to interleukin-1
- NAD biosynthesis via nicotinamide riboside salvage pathway
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- extracellular space
- caveola
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- monooxygenase activity
- heme binding
- prostaglandin-I synthase activity