Ro60 Gene Summary [Mouse]
Enables U2 snRNA binding activity. Acts upstream of or within several processes, including cilium assembly; response to UV; and smoothened signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in embryo. Used to study systemic lupus erythematosus. Orthologous to human RO60 (Ro60, Y RNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ro60 |
| Official Name | Ro60, Y RNA binding protein [Source:MGI Symbol;Acc:MGI:106652] |
| Ensembl ID | ENSMUSG00000018199 |
| Bio databases IDs | |
| Aliases | Ro60, Y RNA binding protein |
| Synonyms | 1810007I17RIK, A530054J02RIK, RO, Ro60, Y RNA binding protein, RORNP, Ro/SS-A, SSA2, SSA-60, SS-A/Ro, TROVE2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ro60 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- U2 snRNA binding
- vWFA
- von Willebrand factor type A domain
- TROVE domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
- breast cancer
- organismal death
- rheumatic disease
- glomerulonephritis
- psoriasis
role in cell
- sensitivity
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cilia
- cell surface
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ro60 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- transcription from RNA polymerase III promoter
- regulation of gene expression
- smoothened signaling pathway
- response to UV
- cellular response to interferon-alpha
- immune system development
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- metal ion binding
- U2 snRNA binding