Ddx6 Gene Summary [Mouse]
Predicted to enable mRNA binding activity and protein domain specific binding activity. Acts upstream of or within negative regulation of neuron differentiation and stem cell population maintenance. Located in P-body. Is expressed in several structures, including brain; early conceptus; neural tube; oocyte; and trunk somite. Orthologous to human DDX6 (DEAD-box helicase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx6 |
| Official Name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Source:MGI Symbol;Acc:MGI:104976] |
| Ensembl ID | ENSMUSG00000032097 |
| Bio databases IDs | |
| Aliases | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 |
| Synonyms | 1110001P04RIK, C430015D01Rik, Dbp6, DEAD box 6, DEAD-box helicase 6, E230023J21Rik, HLR2, IDDILF, mRCK/P54, P54, RCK, Rck/p54, RGD1564560 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphorous-containing acid anhydride hydrolase
- helicase
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein domain specific binding
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- systemic lupus erythematosus
- hereditary disorder
- intellectual developmental disorder with impaired language and dysmorphic facies
- non-small cell lung cancer
- organismal death
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
- systemic sclerosis
role in cell
- expression in
- growth
- production in
- differentiation
- quantity
- proliferation
- apoptosis
- replication in
- cell cycle progression
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- sperm annulus
- heterochromatin
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- Cytoplasm
- perinuclear region
- Plasma Membrane
- polysomes
- cytosol
- sister chromatids
- sperm head
- outer dense fibers
- stress granule
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- viral RNA genome packaging
- stem cell maintenance
- negative regulation of translation involved in gene silencing by miRNA
- neuron differentiation
- negative regulation of neuron differentiation
- cytoplasmic mRNA processing body assembly
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- membrane
- cytosol
- cytoplasmic mRNA processing body
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein domain specific binding
- RNA binding
- protein binding
- RNA helicase activity
- cadherin binding
- mRNA binding
- helicase activity