Mb Gene Summary [Mouse]
Predicted to enable several functions, including nitrite reductase activity; oxygen binding activity; and oxygen carrier activity. Acts upstream of or within several processes, including brown fat cell differentiation; enucleate erythrocyte differentiation; and response to hypoxia. Predicted to be located in sarcoplasm. Is expressed in brown fat; heart; skeletal muscle; and somite. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human MB (myoglobin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mb |
| Official Name | myoglobin [Source:MGI Symbol;Acc:MGI:96922] |
| Ensembl ID | ENSMUSG00000018893 |
| Bio databases IDs | |
| Aliases | myoglobin |
| Synonyms | Glng, myoglobin, MYOSB, PVALB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Globin
- oxygen transporter
- oxygen binding
- peroxidase
- Globin-like protein superfamily
- protein binding
- nitrogenous compound oxidoreductase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- sarcoplasmic body myopathy
- orthostatic hypotension
- ovarian cancer
- growth failure
- Huntington disease
- interstitial fibrosis
- congestive heart failure
- edema
- myocardial ischemia
role in cell
- differentiation
- proliferation
- apoptosis
- motility
- abnormal morphology
- uptake in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- sarcoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- brown fat cell differentiation
- response to hypoxia
- oxygen transport
- removal of superoxide radicals
- enucleate erythrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- sarcoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- oxygen binding
- metal ion binding
- oxygen transporter activity
- heme binding