Prdx2 Gene Summary [Mouse]
Predicted to enable thioredoxin peroxidase activity. Involved in positive regulation of blood coagulation and removal of superoxide radicals. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and respiratory burst involved in inflammatory response. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; limb; reproductive system; and sensory organ. Orthologous to human PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdx2 |
| Official Name | peroxiredoxin 2 [Source:MGI Symbol;Acc:MGI:109486] |
| Ensembl ID | ENSMUSG00000005161 |
| Bio databases IDs | |
| Aliases | peroxiredoxin 2 |
| Synonyms | Band-8, HEL-S-2a, NKEF-B, Peroxiredoxin 2, PRP, PRX2, PRX II, PTX1, TDPX1, TDX1, Thioredoxin dependent peroxide reductase, Torin, TPx, TPX1, TPx-B, TR, TSA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxiredoxin
- peroxidase
- peroxidase (miscellaneous)
- C-terminal domain of 1-Cys peroxiredoxin
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- tyrosine-phenylalanine motif
- thioredoxin peroxidase
- AhpC/TSA family
- enzyme
- antioxidant enzyme
- protein binding
- selenium binding
Pathways
Biological processes and signaling networks where the Prdx2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- rheumatoid arthritis
- neoplasia
- follicular adenoma
- adenoma formation
- survival
- renal clear cell adenocarcinoma
- renal clear cell cancer
- echinocytosis
- Huntington disease
role in cell
- expression in
- apoptosis
- tyrosine phosphorylation in
- growth
- production in
- cell viability
- phosphorylation in
- migration
- proliferation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- Nucleus
- Mitochondria
- cytoplasmic matrix
- cytosol
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of blood coagulation
- extrinsic apoptotic signaling pathway
- regulation of apoptotic process
- cell redox homeostasis
- positive regulation of MAPK cascade
- T cell homeostasis
- thymus development
- hydrogen peroxide catabolic process
- defense response to tumor cell
- response to oxidative stress
- negative regulation of T cell differentiation
- respiratory burst involved in inflammatory response
- leukocyte activation
- removal of superoxide radicals
- negative regulation of apoptotic process
- T cell proliferation
- cellular response to oxidative stress
- cellular response to stress
- response to lipopolysaccharide
- regulation of hydrogen peroxide metabolic process
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- antioxidant activity
- thioredoxin peroxidase activity