Psmd4 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; molecular adaptor activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome accessory complex. Is expressed in brain; liver; and surface ectoderm. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmd4 |
| Official Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [Source:MGI Symbol;Acc:MGI:1201670] |
| Ensembl ID | ENSMUSG00000005625 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 |
| Synonyms | AF, AF-1, angiocidin, ASF, MCB1, Proteasome 26s subunit non-atpase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4, proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pUB-R5, Rpn10, S5A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PUbS domain
- von Willebrand factor (vWF) type A domain
- ubiquitin binding domain
- vWFA
- KEKE domain
- von Willebrand factor type A domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Psmd4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- growth failure
- sickle cell anemia
- productive infection by HIV-1
role in cell
- activation in
- expression in
- phosphorylation in
- proliferation
- binding in
- degradation in
- apoptosis
- phagocytosis by
- adhesion
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- cytosol
- nucleoplasm
- clastosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- cytosol
- proteasome accessory complex
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- polyubiquitin binding
- binding, bridging