Scn1b Gene Summary [Mouse]
Enables sodium channel inhibitor activity. Involved in several processes, including membrane depolarization during cardiac muscle cell action potential; regulation of sodium ion transport; and regulation of ventricular cardiac muscle cell membrane repolarization. Acts upstream of or within several processes, including corticospinal neuron axon guidance; neuronal action potential propagation; and positive regulation of neuron projection development. Located in T-tubule; intercalated disc; and node of Ranvier. Part of voltage-gated sodium channel complex. Is expressed in heart and telencephalon. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn1b |
| Official Name | sodium channel, voltage-gated, type I, beta [Source:MGI Symbol;Acc:MGI:98247] |
| Ensembl ID | ENSMUSG00000019194 |
| Bio databases IDs | |
| Aliases | sodium channel, voltage-gated, type I, beta |
| Synonyms | ATFB13, Beta 1 Nav, BRGDA5, DEE52, EIEE52, GEFSP1, na plus channel β 1 subunit, Na type i, beta, Na type i, β, NAV1.5 beta1 subunit, Nav channel beta1 subunit, Nav channel β1 subunit, sodium channel, voltage-gated, type I, beta, sodium channel, voltage-gated, type I, β, Sodium channel β-1 subunit, sodium voltage-gated channel beta subunit 1, sodium voltage-gated channel β subunit 1, Voltage dependent sodium channel beta1 subunit, β 1 Nav |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scn1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- voltage-gated sodium channel
- cytoplasmic domain
- immunoglobulin domain
- transmembrane domain
- sodium channel regulator
- protein binding
- membrane-proximal domain
- immunoglobulin loop
- ion channel
- Immunoglobulin V-set domain
- sodium channel inhibitor
Pathways
Biological processes and signaling networks where the Scn1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- weight gain
- obesity
- cancer
- traumatic brain injury
- schizophrenia
- schizoaffective disorder
- bipolar disorder
- COVID-19
- vomiting
role in cell
- expression in
- proliferation
- depolarization
- density
- chemorepulsion
- outgrowth
- morphogenesis
- development
- action potential
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane surface
- cellular membrane
- intercellular junctions
- nodes of Ranvier
- nerve ending
- synaptosomes
- intercalated disks
- transverse tubules
- membrane rafts
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scn1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- membrane depolarization involved in regulation of Purkinje myocyte cell action potential
- membrane depolarization involved in regulation of cardiac muscle cell action potential
- corticospinal neuron axon guidance
- regulation of atrial cardiomyocyte membrane depolarization
- locomotion
- axon guidance
- regulation of ventricular cardiomyocyte membrane repolarization
- cell adhesion
- cardiac muscle contraction
- cardiac conduction
- regulation of sodium ion transmembrane transporter activity
- positive regulation of sodium ion transport
- sodium ion transmembrane transport
- regulation of heart rate by cardiac conduction
- positive regulation of neuron projection development
- membrane depolarization
- neuronal action potential propagation
Cellular Component
Where in the cell the gene product is active
- T-tubule
- voltage-gated sodium channel complex
- intercalated disc
- node of Ranvier
- extracellular region
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- protein binding
- voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential
- sodium channel inhibitor activity
- ion channel binding
- voltage-gated sodium channel activity
- voltage-gated sodium channel activity involved in regulation of Purkinje myocyte action potential