Ank3 Gene Summary [Mouse]
This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | Ank3 |
| Official Name | ankyrin 3, epithelial [Source:MGI Symbol;Acc:MGI:88026] |
| Ensembl ID | ENSMUSG00000069601 |
| Bio databases IDs | |
| Aliases | ankyrin 3, epithelial |
| Synonyms | 2900054D09RIK, AnkG, Ankyrin-3, ankyrin 3, epithelial, ANKYRIN-G, MRT37 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ank3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- Ankyrin repeats (many copies)
- channel regulator
- regulatory domain
- membrane-association domain
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- spectrin binding
- sodium channel regulator
- protein binding
- zDHHC ankyrin repeat binding domain
- UPA domain
- ZU5 domain
- Ankyrin repeat
- cytoskeletal protein binding
- structural constituent of cytoskeleton
- spectrin binding domain
- Unc5-PIDD-ankyrin domain
- ion channel binding
- cadherin binding
- spectrin-actin binding domain
- Death Domain Superfamily of protein-protein interaction domains
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- epithelial cancer
- cancer
- COVID-19
- head and neck cancer
- head and neck neoplasia
- liver cancer
- metastatic colorectal cancer
- hepatitis B virus-related hepatocellular carcinoma
- autosomal recessive mental retardation type 37
role in cell
- expression in
- formation
- formation in
- proliferation
- number
- growth
- activation
- differentiation
- maturation
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- glutaminergic synapse
- axon component
- axon initial segment like process
- cytoskeleton
- Cytoplasm
- presynaptic regions
- cell surface
- perijunctional region
- intracellular space
- somatodendritic region
- postsynaptic region
- cellular membrane
- Nucleus
- endosomes
- sarcoplasmic reticulum
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- costameres
- intercellular junctions
- cell-cell contacts
- cytoplasmic aggregates
- cytosol
- postsynaptic membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- Golgi membrane
- nodes of Ranvier
- neuromuscular junctions
- axonal membrane
- neurites
- paranodes
- axon initial segments
- internodes
- synaptosomes
- synapse
- intercalated disks
- sarcolemma
- Z line
- late endosomes
- transverse tubules
- gap junctions
- tight junctions
- perikaryon
- axons
- dendrites
- postsynaptic density
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ank3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of membrane potential
- positive regulation of protein targeting to membrane
- positive regulation of homotypic cell-cell adhesion
- cytoskeleton organization
- signal transduction
- membrane assembly
- regulation of potassium ion transport
- Golgi to plasma membrane protein transport
- establishment of protein localization
- maintenance of protein location in plasma membrane
- neuromuscular junction development
- plasma membrane organization
- cytokinesis after mitosis
- axonogenesis
- positive regulation of gene expression
- cellular response to magnesium ion
- positive regulation of sodium ion transport
- positive regulation of cation channel activity
- positive regulation of cell communication by electrical coupling
- protein localization in plasma membrane
- positive regulation of sodium ion transmembrane transporter activity
- magnesium ion homeostasis
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- sarcoplasmic reticulum
- costamere
- endoplasmic reticulum
- Golgi apparatus
- neuron projection
- plasma membrane
- lysosome
- cell surface
- T-tubule
- dendrite
- Z disc
- initial segment
- basal plasma membrane
- tight junction
- postsynaptic membrane
- sarcolemma
- intercalated disc
- cytosol
- node of Ranvier
- neuromuscular junction
- basolateral plasma membrane
- spectrin-associated cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytoskeletal adaptor activity
- spectrin binding
- cadherin binding
- structural constituent of cytoskeleton
- cytoskeletal protein binding
- ion channel binding
- protein binding, bridging