Arhgef25 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Located in myofibril and plasma membrane. Is expressed in several structures, including brain; eye; gut; metanephros; and otocyst. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Arhgef25 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 25 [Source:MGI Symbol;Acc:MGI:1277173] |
| Ensembl ID | ENSMUSG00000019467 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 25 |
| Synonyms | 2410008H17Rik, 24100H17Rik, D10Ertd610e, GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Arhgef25 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- rotator cuff injury
- Moyamoya disease
role in cell
- activation in
- outgrowth
- adipogenesis
- myogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- axon guidance
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- extrinsic to membrane
- plasma membrane
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity