Pak1 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Located in several cellular components, including dendrite; growth cone; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pak1 |
| Official Name | p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] |
| Ensembl ID | ENSMUSG00000030774 |
| Bio databases IDs | |
| Aliases | p21 (RAC1) activated kinase 1 |
| Synonyms | alpha-PAK, IDDMSSD, Muk2, p21 (RAC1) activated kinase 1, p65-PAK, PAK1B, PAK20, PAKA, PAKalpha, PAK α, α-PAK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pak1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein serine/threonine kinase
- protein kinase
- PAK inhibitory domain
- regulatory domain
- G beta gamma protein binding domain
- ATP-binding domain
- inhibitory domain
- Protein kinase domain
- identical protein binding
- proline rich domain
- Nck-binding domain
- Sh3 domain binding motif
- alcohol group acceptor phosphotransferase
- basic domain
- Tyrosine kinase, catalytic domain
- GTPase binding domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- autoinhibitory protein domain
- autoregulatory domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- protein binding
- polyproline motif
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- gamma-tubulin binding
- kinase domain
- CRIB
- Protein Kinases, catalytic domain
- collagen binding
- PIX binding domain
- Rho-binding domain
- Pak binding domain
Pathways
Biological processes and signaling networks where the Pak1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Amyotrophic Lateral Sclerosis Signaling
- Angiopoietin Signaling
- CCR3 Signaling in Eosinophils
- CXCR4 Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- ErbB Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G Beta Gamma Signaling
- HGF Signaling
- IL-3 Signaling
- LPS-stimulated MAPK Signaling
- Macropinocytosis Signaling
- Molecular Mechanisms of Cancer
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Renal Cell Carcinoma Signaling
- Renin-Angiotensin Signaling
- Semaphorin Signaling in Neurons
- TNFR1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Wilms tumorigenesis
- cancer
- epithelial cancer
- epithelial neoplasia
- liver cancer
- squamous cell cancer
- hepatocellular carcinoma
- skin cancer
- lymphomagenesis
role in cell
- expression in
- function
- proliferation
- activity
- fragmentation in
- formation
- cell death
- apoptosis
- dephosphorylation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- chromatin fraction
- glutaminergic synapse
- ruffle
- focal adhesions
- Nucleus
- Plasma Membrane
- vesicles
- centrosome
- microtubules
- actin filaments
- intercellular junctions
- cytosol
- membrane ruffles
- synaptic membrane
- nucleoplasm
- nuclear envelope
- nuclear matrix
- synaptic vesicles
- growth cone
- synapse
- Z line
- filopodia
- cell membrane leading edge
- filopodial tip
- axons
- dendrites
- postsynaptic density
- phagosomes
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pak1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- negative regulation of cell proliferation involved in contact inhibition
- positive regulation of JUN kinase activity
- positive regulation of cell proliferation
- neuron projection morphogenesis
- protein autophosphorylation
- branching morphogenesis of a tube
- Fc-gamma receptor signaling pathway involved in phagocytosis
- protein phosphorylation
- exocytosis
- stimulatory C-type lectin receptor signaling pathway
- MAPK cascade
- chromatin remodeling
- wound healing
- regulation of axonogenesis
- apoptotic process
- phosphorylation
- positive regulation of microtubule polymerization
- cell migration
- intracellular signal transduction
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of microtubule nucleation
- response to DNA damage stimulus
- hepatocyte growth factor receptor signaling pathway
- regulation of actin cytoskeleton organization
- positive regulation of stress fiber assembly
- ephrin receptor signaling pathway
- positive regulation of protein phosphorylation
- positive regulation of intracellular estrogen receptor signaling pathway
- actin cytoskeleton organization
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- chromosome
- actin filament
- plasma membrane
- nucleoplasm
- dendrite
- Z disc
- centrosome
- nuclear membrane
- cell-cell junction
- focal adhesion
- cytoplasm
- ruffle
- cytosol
- ruffle membrane
- intercalated disc
- macromolecular complex
- axon
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- collagen binding
- small GTPase binding
- protein kinase activity
- gamma-tubulin binding
- protein serine/threonine kinase activity