Rspo3 Gene Summary [Mouse]
Enables frizzled binding activity and heparin binding activity. Involved in blood vessel remodeling; positive regulation of non-canonical Wnt signaling pathway; and sprouting angiogenesis. Acts upstream of or within angiogenesis; branching involved in labyrinthine layer morphogenesis; and positive regulation of canonical Wnt signaling pathway. Located in extracellular region. Is expressed in several structures, including embryo ectoderm; genitourinary system; heart; limb; and skeleton. Orthologous to human RSPO3 (R-spondin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rspo3 |
| Official Name | R-spondin 3 [Source:MGI Symbol;Acc:MGI:1920030] |
| Ensembl ID | ENSMUSG00000019880 |
| Bio databases IDs | |
| Aliases | R-spondin 3 |
| Synonyms | 2810459H04Rik, CRISTIN1, PWTSR, RGD1563246, R-spondin 3, THSD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rspo3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- FU
- frizzled binding
- Furin-like repeat, cysteine-rich
- Furin-like repeats
- receptor binding
- Spondin-like TSP1 domain
- heparin binding
Pathways
Biological processes and signaling networks where the Rspo3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- cleft lip
- epithelial cancer
- Crohn disease
- liver cancer
- bone disorder
- bleeding
- hepatocellular carcinoma
- fracture of bone
- chronic obstructive pulmonary disease
role in cell
- proliferation
- phosphorylation in
- cellular infiltration by
- expression in
- differentiation
- signaling in
- hypertrophy
- stabilization in
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rspo3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blood vessel remodeling
- positive regulation of non-canonical Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- branching involved in labyrinthine layer morphogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- sprouting angiogenesis
- canonical Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- heparin binding
- receptor binding