RSPO3 Gene Summary [Human]
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | RSPO3 |
| Official Name | R-spondin 3 [Source:HGNC Symbol;Acc:HGNC:20866] |
| Ensembl ID | ENSG00000146374 |
| Bio databases IDs | |
| Aliases | R-spondin 3 |
| Synonyms | 2810459H04Rik, CRISTIN1, PWTSR, RGD1563246, R-spondin 3, THSD2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RSPO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- FU
- frizzled binding
- Furin-like repeat, cysteine-rich
- Furin-like repeats
- receptor binding
- Spondin-like TSP1 domain
- heparin binding
Pathways
Biological processes and signaling networks where the RSPO3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- cleft lip
- epithelial cancer
- Crohn disease
- liver cancer
- bone disorder
- bleeding
- hepatocellular carcinoma
- fracture of bone
- chronic obstructive pulmonary disease
role in cell
- proliferation
- phosphorylation in
- cellular infiltration by
- expression in
- differentiation
- signaling in
- hypertrophy
- stabilization in
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RSPO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blood vessel remodeling
- positive regulation of non-canonical Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- branching involved in labyrinthine layer morphogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- sprouting angiogenesis
- canonical Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- heparin binding
- receptor binding