Plin1 Gene Summary [Mouse]
Acts upstream of or within cellular response to cold and lipid catabolic process. Located in cytosol and lipid droplet. Is expressed in blood vessel and connective tissue. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to human PLIN1 (perilipin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plin1 |
| Official Name | perilipin 1 [Source:MGI Symbol;Acc:MGI:1890505] |
| Ensembl ID | ENSMUSG00000030546 |
| Bio databases IDs | |
| Aliases | perilipin 1 |
| Synonyms | 6030432J05Rik, FPLD4, PERI, PERIA, PERILIPIN, perilipin 1, Perilipin a, PLIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amphipathic beta-pleated sheet
- protein binding
- Pka phosphorylation site
- acidic domain
- hydrophobic domain
- Perilipin family
Pathways
Biological processes and signaling networks where the Plin1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- epithelial cancer
- familial partial lipodystrophy type 4
- colorectal cancer
- obesity
- primary bilateral macronodular adrenal hyperplasia
- atopic dermatitis
- osteoarthritis
- hepatocellular carcinoma
- liver cancer
regulated by
- ethanol
- isobutylmethylxanthine
- CTNNB1
- sirolimus
- dexamethasone
- insulin
- SAA
- PKA
- ADH1B
- troglitazone
role in cell
- number
- expression in
- quantity
- accumulation in
- size
- hypertrophy
- accumulation
- interaction in
- lipolysis in
- storage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lipid-rich fraction
- cell surface
- cell periphery
- membrane surface
- cellular membrane
- lipid droplets
- cytosol
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid catabolic process
- lipid metabolic process
- cellular response to cold
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid binding