Epb41l2 Gene Summary [Mouse]
Enables PH domain binding activity and spectrin binding activity. Predicted to be involved in actomyosin structure organization and positive regulation of protein localization to cell cortex. Predicted to act upstream of or within actin cytoskeleton organization and regulation of cell shape. Predicted to be located in several cellular components, including actin cytoskeleton; cell cortex; and nucleoplasm. Predicted to be part of COP9 signalosome. Predicted to be active in cytoskeleton and plasma membrane. Is expressed in several structures, including bone; central nervous system; sensory organ; thymus; and urinary system. Orthologous to human EPB41L2 (erythrocyte membrane protein band 4.1 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epb41l2 |
| Official Name | erythrocyte membrane protein band 4.1 like 2 [Source:MGI Symbol;Acc:MGI:103009] |
| Ensembl ID | ENSMUSG00000019978 |
| Bio databases IDs | |
| Aliases | erythrocyte membrane protein band 4.1 like 2 |
| Synonyms | 4.1-G, D10Ertd398e, Epb4.1l2, erythrocyte membrane protein band 4.1-like 2, NBL2, RGD1563977 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epb41l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- SAB domain
- spectrin binding
- protein binding
- Pleckstrin homology-like domain
- PH-domain binding
- FERM N-terminal domain
- FERM adjacent (FA)
- actin binding
- Ubl1_cv_Nsp3_N-like
- spectrin-actin binding domain
- FERM domain B-lobe
- 4.1 protein C-terminal domain (CTD)
- FERM C-terminal PH-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- aortic valve calcification
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast cancer
- prostate cancer
- neuroticism
- urolithiasis
- male pattern hair loss
- sialadenitis
role in cell
- cell viability
- binding
- morphology
- organization
- Clathrin mediated endocytosis by
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- cellular membrane
- actin cytoskeleton
- cell cortex
- Nucleus
- cell-cell contacts
- cytosol
- periaxonal membranes
- nucleoplasm
- spindle pole
- paranodal loops
- Schmidt-Lanterman incisures
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epb41l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cortical actin cytoskeleton organization
- actomyosin structure organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- focal adhesion
- cell cortex
- cell junction
- cytosol
- signalosome
- spectrin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- spectrin binding
- actin binding
- structural molecule activity
- PH domain binding