Nudt4 Gene Summary [Mouse]
Enables snoRNA binding activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human NUDT4 (nudix hydrolase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt4 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 4 [Source:MGI Symbol;Acc:MGI:1918457] |
| Ensembl ID | ENSMUSG00000020029 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 4 |
| Synonyms | 4933436C10RIK, DIPP-2, DIPP2alpha, DIPP-2B, DIPP2beta, Drcf5, HDCMB47P, KIAA0487, nudix hydrolase 4, NUDT4B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUDIX domain
- diphosphoinositol-polyphosphate diphosphatase
- phosphatase
- snoRNA binding
- protein binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- polyphosphate 25
- 1-diphosphoinositol pentakisphosphate
- phosphate
- bis(1,4)-diphosphoinositol tetrakisphosphate
- P1,P6-di(adenosine-5') hexaphosphate
- HDAC4
role in cell
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- diphosphoinositol polyphosphate metabolic process
- calcium-mediated signaling
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- endopolyphosphatase activity
- snoRNA binding
- protein binding
- bis(5'-adenosyl)-hexaphosphatase activity
- metal ion binding
- bis(5'-adenosyl)-pentaphosphatase activity
- diphosphoinositol-polyphosphate diphosphatase activity
- inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
- inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity